Test Code KPLA Karius Spectrum, Plasma
Specimen Required
Collection Container/Tube:
Preferred: Plasma preparation tube (PPT)
Acceptable: Lavender top (K2 EDTA)
Submission Container/Tube:
Preferred: PPT
Acceptable: Sterile polypropylene tube
Specimen Volume: 1 mL Plasma
Collection Instructions :
1. Gently invert tube 8 to 10 times to mix whole blood.
2. Centrifuge specimen as follows:
a. For PPT: Within 6 hours of collection, centrifuge at 1100 x g for 10 minutes.
b. For K2 EDTA:
i. Within 24 hours of collection, centrifuge at 1600 x g for 10 minutes. For tubes less than 4 mL, refer to tube manufacturer’s instructions for centrifugation speed and time.
ii. Aliquot 1 mL of plasma into a sterile polypropylene tube, taking care not to disturb the buffy coat.
3. For complete instructions see Karius Spectrum Specimen Collection and Preparation Process.
Useful For
Rapid and minimally invasive detection of deep-seated and difficult-to-diagnose systemic infections throughout the body
Provide antimicrobial resistance detection for microbes known to utilize the antimicrobial resistance mechanism
Testing Algorithm
For diagnostic application information see the following:
Karius Spectrum Diagnostic Application Pneumonia
Karius Spectrum: Diagnostic Application Endocarditis
Karius Spectrum: Diagnostic Application Febrile Neutropenia
Karius Spectrum: Diagnostic Application Invasive Fungal Infection
Karius Spectrum: Diagnostic Application Fever of Unknown Origin (FUO)
Method Name
Metagenomic Sequencing
Reporting Name
Karius Spectrum, PSpecimen Type
PlasmaSpecimen Minimum Volume
Plasma: 0.7 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma | Frozen (preferred) | 180 days |
| Ambient | 4 days |
Reject Due To
| Incomplete or improper plasma separation | Reject |
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Saturday
Report Available
2 to 6 daysPerforming Laboratory
Karius LaboratoryTest Classification
The Karius Spectrum test was developed and its performance characteristics determined by Karius. The Karius laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88) and is accredited by the College of American Pathologists (CAP) to perform high-complexity clinical laboratory testing. This test has not been reviewed or cleared by the US Food and Drug Administration.CPT Code Information
0152U
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| KPLA | Karius Spectrum, P | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| KPLA | Karius Spectrum, P | Not Provided |